Search on: COMPLEMENT, C5 
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Descriptor English:   Complement C5 
Descriptor Spanish:   Complemento C5 
Descriptor Portuguese:   Complemento C5 
Synonyms English:   C5 Complement
Complement 5
Complement C5, Precursor
Complement Component 5
Precursor C5
Pro-C5
Pro-complement 5
C5, Complement
C5, Precursor
C5, Precursor Complement
Complement, C5
Component 5, Complement
Precursor Complement C5
Pro C5
Pro complement 5  
Tree Number:   D12.776.124.486.274.450
Definition English:   C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX. 
Pharmacological Action:   Immunologic Factors
 
History Note English:   2006 (1975) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   22137 
Unique Identifier:   D003182 

Occurrence in VHL: 		 

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